Shares of Replimune Group cratered on Tuesday after the biotech said the U.S. Food and Drug Administration rejected an application seeking approval of its experimental skin cancer treatment.Replimune said the agency had issued a complete response letter regarding the company’s biologics license application for RP1, its lead candidate to treat advanced melanoma in conjunction with nivolumab from Bristol Myers Squibb.While the FDA didn’t raise any safety issues, the agency indicated it wouldn’t be able to approve the application in its current form, Replimune said.Shares fell 75% to $3.04, putting the stock on track for a record closing low, according to…
Penulis: beny13
Precancerous cells must adapt to and overcome cellular stress and inflammation in order to progress and form malignant tumors. Now, researchers at University of California San Diego School of Medicine have identified a link between stress and inflammation and pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive and lethal types of cancer. Subscribe to our newsletter for the latest sci-tech news updates. The findings, published in Cell Reports, could serve as an early warning system for the disease, leading to the detection of PDAC before it becomes life-threatening. Previous studies have shown that inflammation and cellular stress activate a…
In November 1922, archaeologist Howard Carter peered through a small hole into the sealed tomb of King Tutankhamun. When asked if he could see anything, he replied: “Yes, wonderful things.” Within months, however, Carter’s financial backer Lord Carnarvon was dead from a mysterious illness. Over the following years, several other members of the excavation team would meet similar fates, fueling legends of the “pharaoh’s curse” that have captivated the public imagination for just over a century. Subscribe to our newsletter for the latest sci-tech news updates. For decades, these mysterious deaths were attributed to supernatural forces. But modern science has…
GoAuto Insurance, a direct-to-consumer auto insurer, has secured approval from the Georgia Office of Insurance and Safety Fire Commissioner to offer insurance policies. This marks the latest expansion for the Baton Rouge-based insurer, which has been offering its services in Louisiana, Nevada, Ohio, Texas and Alabama. GoAuto Insurance COO Brad Scharf said: “Becoming licensed in Georgia and going live with policy issuance is a significant milestone for GoAuto Insurance. “We are committed to making dependable, cost-effective insurance accessible. Georgia drivers now have a fresh new option to meet their insurance needs with convenience and peace of mind.” GoAuto Insurance,…
Ryan Seacrest got emotional when discussing his father Gary’s cancer journey during his radio show On Air with Ryan Seacrest.The 50-year-old showed a more vulnerable side during the show, holding back tears as he shared details of his father’s battle with prostate cancer. Ryan’s father, who turns 81 on July 27, was diagnosed with cancer years ago, according to a 2021 Instagram post by the television personality, though at the time it was undetectable.Unfortunately, the cancer “got worse and it spread,” leaving his father, whom he describes as “strong” and “very smart,” practically immobile for almost five months.Meghan Markle ‘furious’…
An 11-year-old Atlanta Braves fan who captured hearts across Georgia and beyond is now cancer-free.Branson Blevins, who was battling an aggressive form of leukemia, is officially in remission after a last-chance stem cell treatment in Rome, Italy. His latest bone marrow biopsy shows no signs of disease — a result his family had prayed, cried and fought for.While their family was overseas, Branson’s mom, Nichole, even donated her own stem cells in the hope of saving her son’s life. Earlier this summer, 11Alive’s Kaitlyn Ross shared Branson’s story. Learning that he was a huge Braves fan, Kaitlyn put out a call to…
Dear Quentin, I am an old man in my 80s. When I was 50, I retired from a civil-service job after 30 years. When I retired, I took some bad financial advice from a trusted friend who was already retired. This man told me to take my full pension and leave no survivor’s benefits for my wife when I die. He advised me to take out a large term life policy for her instead. My job was stressful and retirees only lived an average of 10 years after retirement, so I thought that this was good advice. I took out…
CLEVELAND, Ohio — Cleveland Clinic London is expanding with the construction of an 81,000-square-foot cancer center expected to open in 2027, the health system recently announced. The new multidisciplinary cancer center will allow Cleveland Clinic London to expand its cancer care, including immunotherapy, chemotherapy, targeted therapies and radiotherapy tailored to each patient. Construction is slated to begin late this year, the Clinic said in a news release. The health system declined to provide the expansion’s cost. In addition to cancer care, Cleveland Clinic London plans to introduce a wider range of clinical services at the new facility, the health system…
Scientists are developing a test that uses a tiny blood sample to detect pancreatic cancer in its early stages.If caught early, pancreatic cancer can potentially be treated. However, patients usually aren’t diagnosed until the cancer has already spread, slashing their chances of survival. The disease is predicted to cause more than 51,000 deaths in the U.S. this year, accounting for over 8% of the nation’s total cancer deaths.One reason pancreatic cancer is often diagnosed at an advanced stage is that doctors have no routine screening tests for the disease, although some tests are being explored for people known to be…
Scientists have uncovered a molecular “on–off” switch that helps lung adenocarcinoma—the most common form of lung cancer—grow and spread. The discovery pinpoints the protein calcyclin‑binding protein (CACYBP) as a key driver of tumor activity and suggests that blocking it could improve outcomes for patients who fail to benefit from current drugs. The study is published in the journal Biomolecules and Biomedicine. Subscribe to our newsletter for the latest sci-tech news updates. Non‑small‑cell lung cancer (NSCLC) causes the majority of lung‑cancer deaths, and the adenocarcinoma subtype accounts for roughly 60% of NSCLC cases. Because early‑stage LUAD rarely produces symptoms, most patients…